Linear plasmids in Streptomyces.
نویسندگان
چکیده
منابع مشابه
Isolation and characterization of plasmids from Streptomyces.
In view of the importance of actinomycetes in the production of antibiotics, it would be useful to find plasmids in these organisms in order to construct molecular breeding systems. Since the first discovery of plasmid involvement in antibiotic production", several plasmids associated with the production of antibiotics have been found in Streptomyces (references are listed in AKAGAWA et al.-')....
متن کاملLinear Streptomyces plasmids form superhelical circles through interactions between their terminal proteins
Linear chromosomes and linear plasmids of Streptomyces possess covalently bound terminal proteins (TPs) at the 5' ends of their telomeres. These TPs are proposed to act as primers for DNA synthesis that patches the single-stranded gaps at the 3' ends during replication. Most ('archetypal') Streptomyces TPs (designated Tpg) are highly conserved in size and sequence. In addition, there are a numb...
متن کاملTelomere-associated proteins add deoxynucleotides to terminal proteins during replication of the telomeres of linear chromosomes and plasmids in Streptomyces
Typical telomeres of linear chromosomes and plasmids of soil bacteria Streptomyces consist of tightly packed palindromic sequences with a terminal protein ('TP') covalently attached to the 5' end of the DNA. Replication of these linear replicons is initiated internally and proceeds bidirectionally toward the telomeres, which leaves single-strand overhangs at the 3' ends. These overhangs are fil...
متن کاملRecruitment of terminal protein to the ends of Streptomyces linear plasmids and chromosomes by a novel telomere-binding protein essential for linear DNA replication.
Bidirectional replication of Streptomyces linear plasmids and chromosomes from a central origin produces unpaired 3'-leading-strand overhangs at the telomeres of replication intermediates. Filling in of these overhangs leaves a terminal protein attached covalently to the 5' DNA ends of mature replicons. We report here the essential role of a novel 80-kD DNA-binding protein (telomere-associated ...
متن کاملLarge linear plasmids of Borrelia species that cause relapsing fever.
Borrelia species of relapsing fever (RF) and Lyme disease (LD) lineages have linear chromosomes and both linear and circular plasmids. Unique to RF species, and little characterized to date, are large linear plasmids of ∼160 kb, or ∼10% of the genome. By a combination of Sanger and next-generation methods, we determined the sequences of large linear plasmids of two New World species: Borrelia h...
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ژورنال
عنوان ژورنال: Journal of the agricultural chemical society of Japan
سال: 1990
ISSN: 0002-1407,1883-6844
DOI: 10.1271/nogeikagaku1924.64.50